Common use
Tamodex is a non-steroid anti-estrogen that competitively inhibits estrogen receptors in the target organs and tumors in them. Mechanism of its action is not completely investigated, though it is known that a complex of Tamodex with the receptor and cofactor appears, and then it is transferred to the cell nucleus, preventing hypertrophy of the cells which depend on regulation by estrogen. The effect of the medication can last several weeks after a single dose. Tamodex is able to cause ovulation in women, stimulate the production of gonadotropic hormones of the hypophysis. In men with oligospermia, it increases the concentration of luteinizing hormone and follicle-stimulating hormone, testosterone, and estrogen in the blood serum. Tamodex is used to treat breast cancer in women and in men (especially after castration) and also when it has spread to other parts of the body, kidney cancer, melanomas, and sarcomas of the soft tissues with estrogen receptors, cancer of the ovary.
Dosage and direction
Take it exactly as recommended by your physician, as the dosage depends on your condition. Long treatment (about 2 years) is advised. Take this medication with food and a big glass of water as a single dose or divide it in two (taken in the morning and the evening). Do not chew or crush them.
Precautions
This medication may increase the possibility of developing endometrial cancer. Patients who are treated with Tamodex should be monitored for any abnormal vaginal bleeding, changes in menstrual periods, changes in vaginal discharge, or pelvic pain or pressure.
Contraindications
Tamodex is contradicted in patients with hypersensitivity to this medication and also in women who are treated by coumarin-type anticoagulant therapy or in women with deep vein thrombosis or pulmonary embolus in history, pregnant or breastfeeding women. Cautiousness should be exercised in patients with eye diseases (including cataracts), hyperlipidemia, leukopenia, thrombocytopenia, hypercalcemia, severe thrombophlebitis, thromboembolism (also in history).
Side effects
Side effects are not expected. If they change from minor to severe, you should immediately inform your doctor about it. Side effects caused by Tamodex are: hot flashes, nausea, vomiting, weight gain, abnormal menstrual periods.
Drug interaction
Tamodex is able to cause abnormalities in liver and blood tests, so regular monitoring of side effects caused by Tamodex is required. If such signs as jaundice and bleeding appear, a patient should immediately seek immediate medical help.
Missed dose
If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usual dose the next day at the same regularly scheduled time.
Overdose
Acute overdosage in humans has not been reported. In patients with metastatic cancer treated with the maximally tolerated doses of Tamodex, acute side effects manifested by tremor, hyperreflexia, unsteady gait, and dizziness were observed. If you suspect that you took too much of this medication, look for immediate medical help and contact your doctor.
Storage
Store at room temperature between 20-25 C (68-77 F).
Disclaimer
We provide only general information about medications, which does not cover all directions, possible drug interactions, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your healthcare adviser or doctor in charge of the case. We disclaim reliability of this information and any mistakes it could contain. We are not responsible for any direct, indirect, special, or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.