Common use
Danogen is a synthetic steroid produced from ethisterone. This medication suppresses the synthesis of gonadotrophic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by the pituitary gland in men and women. In women, this drug inhibits the activity of the ovaries, ovulation, and leads to atrophy of the endometrium. The medication is used to treat endometriosis (associated with sterility), fibrocystic breast disease, to prevent attacks of inherited angioedema, benign breast tumors (fibrocystic breast), menorrhagia (abnormally heavy and prolonged menstrual periods), premenstrual syndrome, primary premature puberty, gynecomastia.
Dosage and direction
The common recommended dose in adults is 200-800 mg a day, divided into 2-4 intakes. Treatment starts on the first day of the menstrual cycle. To treat severe endometriosis, the initial daily dose is 400 mg, later the dose may be increased to 800 mg by your physician. Treatment continues for six months. In children with premature puberty, the dose is 100-400 mg.
Precautions
Cautiousness should be exercised in patients with diabetes mellitus, epilepsy, migraine. Use reliable and effective forms of contraception while you are on Danogen, such as a condom or diaphragm with spermicide gel or inserts, as hormonal forms of contraception may turn out to be ineffective. Dose correction is needed in patients with diabetes. Take this drug according to the instructions of your doctor. Do not exceed the recommended dose. Women may need to start Danogen during their menstrual period. This medication may change the results of some medical tests; inform your doctor if you take this medication. Do not start or stop this medication without the approval of your doctor, continue to take it even if you do not notice immediate positive results of treatment. If your symptoms do not improve in two months, inform your doctor.
Contraindications
This medication cannot be used in patients with hypersensitivity to Danogen or its components, in pregnant and breastfeeding women, porphyria (activity of liver transaminases increases), liver or kidney failure, chronic heart failure, thromboembolism, androgen-producing tumor, vaginal bleeding of unknown origin.
Side effects
The most common side effects include signs of allergy (hives, rash, facial swelling, difficulty breathing) and also sudden numbness or weakness, angina, sudden cough, wheezing, rapid breathing, fast heart rate, sudden problems with vision, speech, or balance, confusion, swelling, feeling short of breath, rapid weight gain, headache, vision problems, ringing in the ears, dizziness, nausea, loss of appetite, dark urine, pain behind the eyes, stomach pain, and jaundice.
Drug interaction
Danogen increases the effects of anticoagulants of the coumarin series and derivatives of indandione, such as the risk of bleeding. Danogen decreases the effects of insulin and oral hypoglycemic drugs by affecting the metabolism of carbohydrates, increasing blood sugar levels. Danogen inhibits the metabolism of carbamazepine and increases its blood levels, and increases blood concentrations of cyclosporine and tacrolimus, thereby increasing the risk of nephrotoxicity. Danogen also increases serum levels of glucagon.
Missed dose
Take the missed dose as soon as you remember. If it is almost time for your next dose, just skip the missed dose and return to your schedule. Do not double dose this medication to make up the missed dose.
Overdose
This medication is not likely to produce life-threatening symptoms. The most common effects of overdose are weight gain, menstrual problems, increased acne or facial hair growth, and breast changes.
Storage
Store at room temperature between 20-25°C (68-77°F). Store away from moisture, heat, and sunlight. It is not recommended to store in a bathroom and places available for children.
Disclaimer
We provide only general information about medications, which does not cover all directions, possible drug interactions, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed upon with your health care adviser or doctor in charge of the case. We disclaim the reliability of this information and any mistakes it could contain. We are not responsible for any direct, indirect, special, or other indirect damage as a result of any use of the information on this site, and also for consequences of self-treatment.